What is GASTROClear?
Certain gastric cancer screening tests can be rather invasive and have side effects, making individuals hesitant to go in for a screening. For example, if not done right, endoscopies like a deep enteroscopy could be uncomfortable and certain biopsies could even lead to bleeding. This is certainly not always the case, especially if your doctor is careful in their handling of the procedure, but, if you’re still searching for a less invasive procedure; consider GASTROClear in Singapore. The GASTROClear screening method is the world’s first molecular blood test developed in Singapore used to detect early-stage stomach (also known as gastric) cancer. GASTROClear detects all stages of stomach cancer with up to 86% sensitivity and up to 89% specificity in an asymptomatic average-risk population.
The novelty of the GASTROClear test lies in its non-invasive nature and accuracy in detecting stomach cancer in its early stages, when symptoms are not present. This is a useful option for patients who are not keen on gastroscopic screening, and helps your gastroenterologist assess your risk for stomach cancer, and discern whether a gastroscopy is necessary.
How does GASTROClear work?
The GASTROClear test is conducted by drawing your blood and sending it to a MOH-certified lab to measure the levels of microRNA in the blood, specifically picking up 12 microRNAs that are associated with gastric cancer in a single blood draw (5ml).
MicroRNA, also known as miRNA, are found in the bloodstream. They are a family of molecules that help cells control the amount of protein they synthesise. Essentially, they are used by cells to control gene expression. After these microRNAs are measured, they are translated into a risk score which is calculated by a clinically approved proprietary algorithm. Thereafter, you will be classified according to your risk score as low risk, intermediate risk, or high risk.
After the procedure is conducted and your risk score is determined, your doctor will follow up with you and provide recommendations on managing your particular risk group. You can expect your GASTROClear screening report within 7-10 working days.
Minimally Invasive
Only requires onesingle draw ofblood (5ml)
Detects risk of gastric cancer before symptomsappear
Higher accuracy for detecting gastric cancer inits earlier stages
Who should get a GASTROClear test?
Adults of both genders at age 40 years and above can get a GASTROClear screening done. Furthermore, this test is recommended for individuals at higher risk for gastrointestinal issues. You could be at higher risk if:
- You have a family history of stomach cancer
- You have a history of Helicobacter pylori (H.pylori) infection
- You suffer from continued stomach inflammation or chronic gastritis
- You have a high intake of fried foods, smoked foods, salted fish, processed meats, pickled foods, and food containing nitrites and nitrates (commonly found in cured meats)
- You have a low intake of fruits and vegetables
- You frequently smoke and/or drink alcohol
Why should I undergo regular GASTROClear screening?
An early diagnosis is crucial to minimise the negative effects of cancer. Unfortunately, the majority of early-stage stomach cancer patients do not show symptoms, which leads to a late diagnosis. Stomach cancer patients have a 70% higher chance of surviving more than 5 years when detected early. Therefore, effective and early screening can detect cancer cells earlier, increasing your survival rate and minimising the cost of treatment and the recovery period.
How often should I get a GASTROClear test done?
Stomach cancer can be cured when cancer cells are detected early before any symptoms start to show.
Depending on your age and certain risk factors (based on diet and lifestyle), you can repeat a GASTROClear test based on your score results.
How much is GASTROClear in Singapore?
GASTROClear is priced at around $300 before GST.
How accurate is GASTROClear?
GASTROClear has a higher detection rate than traditional cancer markers. In recent clinical trials, the test detected 87.5% stage I and 89.5% stage II stomach cancers.
Furthermore, studies have shown that GASTROClear is 20% more accurate than other blood-based biomarker tests for stomach cancer.
GASTROClear Higher Detection Rate
Summary
Stomach cancer is the fourth leading cause of cancer death in the world based on the World Health Organisation (WHO), with East Asian countries accounting for half of the world’s stomach cancer incidences. Thankfully, stomach cancer can be treated in its early stages, — making early detection crucial. A GASTROClear test is a non-invasive and blood-based test that can detect early-stage stomach cancers. We hope this guide has provided you with a better understanding of what to expect from a GASTROClear test. If you have any further questions, you may contact one of our friendly staff at Alpha Digestive and Liver Centre who will be happy to answer any further queries you may have.
References
- NS Medical Devices | Singapore scientists develop new blood test for early diagnosis of gastric cancer, https://www.nsmedicaldevices.com/news/singapore-scientists-gastroclear-gastric-cancer/. Accessed 26 October 2022.
- The Straits Times | Blood test for early detection of gastric cancer being evaluated for use in primary healthcare, https://www.straitstimes.com/singapore/blood-test-for-early-detection-of-gastric-cancer-being-evaluated-for-use-in-primary. Accessed 26 October 2022.
- Molecular Diagnostic Laboratory | GASTROClear Test, https://www.ttsh.com.sg/Patients-and-Visitors/Documents/GASTROClear%20Test.pdf. Accessed 26 October 2022.
- Mirxes | GASTROClear for Professionals, https://mirxes.com/gastroclear-professionals-old/. Accessed 26 October 2022.
